Indication & Dosage |
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| Oral |
| PAGET'S DISEASE OF BONE |
| Adult:
30 mg once daily for 2 mth, repeat if necessary after 2 mth interval. |
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| Oral |
| TREATMENT OR PREVENTION OF POSTMENOPAUSAL OR CORTICOSTEROID-INDUCED OSTEOPOROSIS |
| Adult:
5 mg daily. To minimize GI effects, take with at least 200 ml of water in an upright position on an empty stomach, at least 30 min before breakfast and any other oral medication. Remain upright after taking the tab for at least 30 min. Do not take at bedtime or before rising. For postmenopausal osteoporosis, 35 mg once wkly may be given. |
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| Oral |
| INCREASE BONE MASS IN MEN WITH OSTEOPOROSIS |
| Adult:
35 mg once wkly. |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (5 mg tab to be taken at least 30 mins before the 1st food/drink/med of the day; or at least 2 hr from any food or drink at any other time of the day, & at least 30 mins before going to bed. 35 mg tab to be taken at least 30 mins before the 1st food/drink/med of the day. 5mg & 35 mg tab: Take w/ a full glass (≥120 mL) of plain water while in an upright position. Do not lie down for at least 30 mins after taking. Swallow whole, do not chew/crush/suck.) |
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| Precautions |
Correct hypocalcaemia prior to therapy. Monitor hepatic and renal function and WBC. Renal impairment; inability to remain in an upright position for at least 30 min after oral intake. |
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| Adverse Drug Reactions |
Electrolyte disturbances; GI disturbances; musculoskeletal pain; headache; hypersensitivity reactions; blood disorders; liver enzyme disturbances. Bone, joint and/or muscle pain. |
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| Interactions |
Co-admin with calcium, antacids or oral medications containing divalent cations may affect the absorption of risedronate. May have additive calcium lowering effects when used with aminoglycosides. |
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